Single-cell analysis of Crohn's disease reveals a detailed picture of inflammation in the gut

Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn
Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn's disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal pain, diarrhea, and weight loss. The disease is difficult to treat and often requires hospitalization.

A single-cell atlas of nerve cells in the gut reveals web of connections

Medical Xpress Archive : 31/01/2023( continued page 10)

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy - ScienceDirect

Stricturing Crohn's Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions - ScienceDirect

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study, BMC Medicine

10 New Genetic Variants of Crohn's Disease Susceptibility Uncovered

Crohn's Disease Features in Anastomotic Biopsies from Patients With and Without Crohn's Disease: Diagnostic and Prognostic Value - Modern Pathology

Two previously unknown bacterial species identified from patients with inflammatory bowel disease

Intestinal cellular heterogeneity and disease development revealed by single -cell technology, Cell Regeneration

Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn's Disease

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Mapping the second brain: Single cell characterization of the enteric nervous system reveals clues to IBD - 10x Genomics

What is the Gut Microbiome?

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